“Negligence” (pamāda) is from a root meaning to be mad or drunk. It’s often used in an ethical context, but here the Buddha extends it throughout the path.

The discourse links “negligence” with the process of mental uplifting that leads to samādhi (see SN 12.23:3.11).

“Principles” (dhammā) such as the four noble truths, dependent origination, etc.